Drug pipeline
NEXT
Neurodegeneration
We pursue a variety of promising protein kinase targets that have the potential to slow down, stop, or even revert the progression of Parkinson’s Disease (PD), Alzheimer’s Disease (AD) and other forms of acute and chronic neurodegeneration. We target both, the underlying cause of the disease like spreading of a-synuclein or phosphorylation of tau and amyloid-beta, and the corresponding microglia activation, cytokine signaling, and neuroinflammation. We have built a synergistic portfolio of highly selective, brain-penetrating small molecule drugs that have a high potential to become game-changers in the treatment of the largest burden for the aging and growing population.
Drug Pipeline
Our drug pipeline consists of preclinical small molecule drugs that are designed to hit select targets with high potency and outstanding selectivity in difficult-to-reach tissues of interest like the brain or the eye.
These novel targeted therapies are entirely based on the application of our AI and wet-lab technology platform. We leverage synergies in the physiological disease mechanisms, the molecular targets, and the compound mode of action to target unmet medical needs. Our therapeutic small molecule research and development includes the simultaneous exploration and optimization of target-specific PET tracers as preclinical tools and clinical direct biomarkers.
Brain cancer
The vast majority of the approved anticancer drugs do not sufficiently cross the blood-brain-barrier. This means that metastasizing cells can hide and spread in the brain as the drug cannot reach an effective concentration there to fight them. In addition, primary brain cancers like glioblastoma represent a high unmet medical need.
We have created a portfolio of brain-penetrating small molecules that hit validated anticancer targets in the brain and in the system, thus aiming at the redefinition of the standard-of-care in cancer treatment.
Ophthalmology
The eye represents a particular organ that can be targeted systemically and topically. Topical administration to the eye, in particular as eye drops, has the advantage of a minimal drug exposure and reduction of unwanted side-effects in the body. In order to be efficacious and long-lasting, the small molecule drugs must display a very specific set of properties to reach the eye tissue, which is protected by a three-layer tear film.
We pursue novel targets to combat the sight-threatening host response to eye infection by fungi, virus, and bacteria. In addition, we target other forms of eye inflammation and tissue degeneration, as well as allergic conditions, to preserve and improve patient’s precious vision.
